|Selected Document Category:||Published Document|
|Source:||International Organization for Standardization|
|Anticipated Publication Year:||2016|
|Document Title:||Detection and sizing of nanoparticles in aqueous media via single particle inductively coupled plasma mass spectrometry (ICP-MS)|
This ISO TS specifies a test method for the detection and characterisation of nanoparticles in aqueous suspensions. Characterisation is specified here as the particle number and mass concentration and the number-based size distribution (assuming a spherical geometry of the individual particles).
The test method is applicable for the determination of the size of inorganic nanoparticles, metal and metal oxides (e.g. Ag, Au, TiO2 etc.), with size ranges of 10 nm to 100 nm in aqueous suspensions. Particle number concentrations that can be determined in aqueous suspensions range from 105 to 109 particles/L which corresponds (depending on the type of material) to mass concentrations in the range of 1 to 1,000 ng/L. Actual numbers depend on the type of mass spectrometer used and the type of nanoparticle analysed.
In addition to the particle concentrations, ionic concentrations can also be determined.
The test method is restricted to aqueous suspensions. The samples can be aqueous suspensions of the pure nanoparticles, aqueous extracts from materials or consumer products, aqueous digests of food or tissue samples, aqueous toxicological samples, or environmental water samples. Information about sample processing of non-aqueous samples can be found in the literature. Aqueous environmental samples are filtrated and diluted, food and toxicological samples are chemically or enzymatically digested and diluted. However, to relate particle number or mass concentrations in aqueous suspensions to the concentrations in the original sample requires information on extraction efficiency and matrix effects. Additional validation is required.
The method proposed in this document is not applicable for the detection and characterisation of organic or carbon-based nanoparticles like encapsulates, fullerenes and carbon nanotubes (CNT).
|Keywords:||nanoparticles, aqeuous solutions, ICP-MS, particle concentration|
|Type of Document:||a. Standard|
|Issues Areas:||Health, Safety, and Environment|
|Goal or Need:||This ISO/TS is being developed in response to the worldwide demand of suitable methods for the detection and characterisation of nanoparticles in food and consumer products. Products based on nanotechnology or containing engineered nanoparticles are already used in different fields and are beginning to impact the food associated industries and markets. As a consequence, direct and indirect consumer exposure to engineered nanoparticles (in addition to natural nanoparticles) becomes more likely. The detection of engineered nanoparticles in food, in samples from toxicology and exposure studies therefore becomes an essential part of understanding the potential benefits as well as the potential risks of the application of nanoparticles.|
|Is it Being Implemented:|
|Submitter's Name:||Heather Benko|
|Submitter's Company:||American National Standards Institute|
|Contact for Additional Info:||Toshiyuki Fujimoto, T.Fujimoto at aist.go.jp|