114

Selected Document Category:	Published Document
Source:	Nanotechnology Characterization Laboratory
Anticipated Publication Year:
Publication Year:	2009
Acronym:	NCL
Identifier:	ITA-3
Document Title:	Mouse Granulocyte-Macrophage Colony-Forming Unit Assay
url:	http://ncl.cancer.gov/NCL_Method_ITA-3.pdf
Scope:	Myelosuppression is a common dose limiting toxicity of cytotoxic oncology drugs. Nanoparticles may distribute to bone marrow and/or release drug that distributes to bone marrow. Therefore, understanding potential toxicity of nanoparticles or drugs which nanoparticles carry is an important step in preclinical safety evaluation. This document describes a protocol for quantitative analysis of granulocyte-macrophagecolony-forming units, employing murine bone marrow (BM).
Keywords:	BM, granulocyte macrophagecolony, Myelosuppression
Type of Document:	e. Specification
Issues Areas:	Measurement and Characterizations Health, Safety, and Environment
Primary Category:	Chemicals e.g. pesticides, pharmaceuticals, paints, basic chemicals
Additional Categories
Goal or Need:
Intended Stakeholders:
Is it Being Implemented:
Submitter's Name:	Admin
Submitter's e-mail:	[email protected]
Submitter's Company:	ANSI
Additional Comments:
Contact for Additional Info:	http://ncl.cancer.gov/working_assay-cascade_download.asp

Selected Document Category:	Published Document
Source:	Nanotechnology Characterization Laboratory
Anticipated Publication Year:
Publication Year:	2009
Acronym:	NCL
Identifier:	ITA-3
Document Title:	Mouse Granulocyte-Macrophage Colony-Forming Unit Assay
url:	http://ncl.cancer.gov/NCL_Method_ITA-3.pdf
Scope:	Myelosuppression is a common dose limiting toxicity of cytotoxic oncology drugs. Nanoparticles may distribute to bone marrow and/or release drug that distributes to bone marrow. Therefore, understanding potential toxicity of nanoparticles or drugs which nanoparticles carry is an important step in preclinical safety evaluation. This document describes a protocol for quantitative analysis of granulocyte-macrophagecolony-forming units, employing murine bone marrow (BM).
Keywords:	BM, granulocyte macrophagecolony, Myelosuppression
Type of Document:	e. Specification
Issues Areas:	Measurement and Characterizations Health, Safety, and Environment
Primary Category:	Chemicals e.g. pesticides, pharmaceuticals, paints, basic chemicals
Additional Categories
Goal or Need:
Intended Stakeholders:
Is it Being Implemented:
Submitter's Name:	Admin
Submitter's e-mail:	[email protected]
Submitter's Company:	ANSI
Additional Comments:
Contact for Additional Info:	http://ncl.cancer.gov/working_assay-cascade_download.asp

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