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Selected Document Category:	Published Document
Source:	Nanotechnology Characterization Laboratory
Anticipated Publication Year:
Publication Year:	2011
Acronym:	NCL
Identifier:	GTA-12
Document Title:	Autophagic Dysfunction in LLC-PK1 Cells
url:	http://ncl.cancer.gov/NCL_Method_GTA-12.pdf
Scope:	Lysosomal dysfunction is recognized as a potential toxic mechanism for xenobiotics that can result in various pathological states(1). There is concern that nanopaticles, in particular, maycause lysosomal pathologies,since they are likely to accumulate within lysosomes (2). Lysosomal dysfunction could potentially result from biopersistance, or inhibition oflysosomal enzymes, such as inhibition of phospholipase resulting in phospholipidosis, or inhibition of lysosomal protein degradation resulting in lysosomal overload.
Keywords:	lysosomes, phospholipase
Type of Document:	e. Specification
Issues Areas:	Measurement and Characterizations Health, Safety, and Environment
Primary Category:	Chemicals e.g. pesticides, pharmaceuticals, paints, basic chemicals
Additional Categories
Goal or Need:
Intended Stakeholders:
Is it Being Implemented:
Submitter's Name:	Admin
Submitter's e-mail:	[email protected]
Submitter's Company:	ANSI
Additional Comments:
Contact for Additional Info:	http://ncl.cancer.gov/working_assay-cascade_download.asp

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