Selected Document Category:Published Document
Source:National Institute of Standards and Technology-Nanotechnology Characterization Laboratory
Anticipated Publication Year:
Publication Year:2010
Document Title:Quantification of Free and Chelated Gadolinium Species in Nanoemulsion-Based Magnetic Re sonance Imaging Contrast Agent Formulations using Hyphenate d Chromatography Methods
Scope:Gadolinium-based magnetic resonance imaging (MRI) contrast agent (CA) formulations have been routinely applied in the clinical setting to improve differentiation among neighboring tissues of interest. Although the free gadolinium ion has potentially toxic effects in vivo, complexation of the ion by various ligands has been shown to improve acute tolerance. Nanoemulsion-based CAs, which use liposomal ligands to chelate the gadolinium, have shown promise as highly potent contrast agents, due to their accommodation of a significantly higher gadolinium payload, improved relaxivities, and reduced incidents of release of gadolinium ions compared to traditional CAs. With the advent of these new types of gadolinium-ligand complexes, it remains crucial to measure the amounts of total, bound, and uncomplexed gadolinium in CA formulations.
Keywords:CA, MRI
Type of Document:e. Specification
Issues Areas:Measurement and Characterizations
Health, Safety, and Environment
Primary Category:Chemicals e.g. pesticides, pharmaceuticals, paints, basic chemicals
Additional Categories
Goal or Need:
Intended Stakeholders:
Is it Being Implemented:
Submitter's Name:Admin
Submitter's e-mail:SCulley@ansi.org
Submitter's Company:ANSI
Additional Comments:
Contact for Additional Info:http://ncl.cancer.gov/working_assay-cascade_download.asp