Selected Document Category:Published Document
Source:Nanotechnology Characterization Laboratory
Anticipated Publication Year:
Publication Year:2013
Document Title:This protocol assumes an intermediate level of scientific competency with regard to techniques, instrumentation, and safety procedures. Rudimentary assay details have been omitted for the sake of brevity. NCL Method GTA - 13

Characterization of drug release under physiological conditions is very important for prediction of drug release in vivo, and can be used for formulation optimization.
This assay uses a blood partitioning technique to measure the release of free drug from a
nanoparticle-encapsulated drug complex. This assay is based on the principle that the free
drug will partition between the plasma andred blood cell (RBC)fractions, whereas the hydrophilic nanoparticle platform is generally retained in the plasma fraction.

Keywords:hydrophilic nanoparticle platform, RBC, in vivo
Type of Document:e. Specification
Issues Areas:Measurement and Characterizations
Health, Safety, and Environment
Primary Category:Chemicals e.g. pesticides, pharmaceuticals, paints, basic chemicals
Additional Categories
Goal or Need:
Intended Stakeholders:
Is it Being Implemented:
Submitter's Name:Admin
Submitter's e-mail:SCulley@ansi.org
Submitter's Company:ANSI
Additional Comments:
Contact for Additional Info:http://ncl.cancer.gov/working_assay-cascade_download.asp